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Microglia in the developing brain are also sensitive to external perturbations such as maternal infections (Smolders et al., 2015

Since the introduction of kava consumption to Western society, other solvents have been used to optimize the kavalactone extraction yield, often resulting in higher concentration of these active compounds, but also other potentially less desirable (even dangerous, see later discussion) flavokavains and alkaloids [15,32,35,38,40,41]