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Crucially, HBV independently suppresses DNA repair capacity by downregulating poly(ADP-ribose) polymerase 1 (PARP1) via YTHDF2-mediated m6A methylationwithout enhancing ROS production or altering oxidative stress pathways [389, 391]

Ethics declarations Ethics approval and consent to participate This study was performed with the approval of the Ethics Committee of Harbin Institute of Technology University and carried out in compliance with the Declaration of Helsinki of the World Medical Association

O -Benzyl ethers of (2 S ,4 R )- 3 and (2 S ,4 S )- 3 were prepared by the same methodology [50]

HMGB1 acts as both a trigger and amplifier of ferroptosis, engaging receptors such as TLR4 and RAGE to propagate inflammation and tissue injury