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For truly oxidation-sensitive peptides, investing in a small nitrogen or argon cylinder with appropriate regulator can significantly extend shelf life

NO helps counteract oxidative stress and is involved in the management of hypoxia-related disorders by improving erythrocyte deformability, thereby supporting more efficient oxygen delivery and better clinical outcomes ( Various protein kinases and phosphatases tightly regulate erythrocyte signal transduction, allowing rapid responses to hypoxia, metabolic shifts, oxidative stress, and shear forces

Milward et al., A mild phenotype was also reported in two patients with compound heterozygous mutations (Fang et al., STAT5B mutations STAT5B mutations present a characteristic phenotype combining GHI and immunodeficiency (OMIM #245590)

Significance level were denoted by * p 0.05