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(2) There is no urgent need for Cm effectors to inhibit certain specified plant defense responses in the pathogenic process of necrotrophs 78 , so the evolutionary selection pressure does not force necrotrophs to evolve enzymatic functional Cm effectors

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Conservative amino acid substitutions include the substitution of an amino acid in one class by an amino acid of the same class, where a class is defined by common physicochemical amino acid side chain properties and high substitution frequencies in homologous proteins found in nature, as determined, for example, by a standard Dayhoff frequency exchange matrix or BLOSUM matrix