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To address these issues, researchers have proposed various enhancements, such as introducing symmetry in adversarial training and refining loss functions to stabilize learning and improve sample diversity [79]

Brucein D, a naturally occurring quassinoid, enhances the sensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to gemcitabine (GEM) by promoting the ubiquitin-proteasome-dependent degradation of NRF2 and suppression of the NRF2 signaling pathway [104]

PMID: 26220150

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