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Generic Name: Thiamine Hydrochloride + Pyridoxine Hydrochloride + Cyanocobalamin

TIKOSYN is also contraindicated in patients with severe renal impairment (calculated creatinine clearance 90%, with maximal plasma concentrations occurring at about 23 hours in the fasted state

Additionally, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) facilitated AML development and LSCs self-renewal through regulating the expression of key targets in the glutamine metabolic pathway [23]

As there is less variation in the production and breakdown of cystatin C compared to creatinine across populations, and because it is less influenced by body composition, cystatin C is considered a more accurate marker of kidney function