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In addition to impairing insulin signaling, adipocyte derived FAs can also impact gluconeogenesis in the liver, where a hallmark of T2D is the loss of the inverse relationship between gluconeogenesis and lipogenesis

CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells

As the skin heals, the redness and swelling generally subside within a few days

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval