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Xenobiotics may be detoxified in conjugation reactions with glutathione catalyzed by glutathione S-transferase, which activity is constitutive

Catale C, Martini A, Piscitelli RM, Senzasono B, Iacono LL, Mercuri NB, et al

This neuroadaptation forms the mechanistic basis for withdrawal phenomena and explains why withdrawal symptoms tend to be predominantly hyperarousal in nature, including anxiety, insomnia, tremor, and autonomic symptoms