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The systemic response initiates with a rapid increase of pro-inflammatory components (IL-6, IL-8), which in turn generates an anti-inflammatory feedback by increasing the release of interleukin (IL)-10 and interleukin (IL)-1 receptor antagonist [70]

Accordingly, preclinical data correlate the environmental disruption of the biological clock, due to shift work and light exposure at night, with hormone-dependent cancers, such as breast and prostate cancer 100,101,102

For example, Plasmodium falciparum induces DNA damage, which can turn EBV-infected B cells into eBL

The DNA-binding study using agarose gel electrophoresis showed that these complexes interacted with genomic DNA