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[DOI] [PubMed] [Google Scholar] Makino Y, Sakagami H, Takeda M

Shah A, Kumar S, Simon SD, Singh DP, Kumar A

This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

it catalyses the biotransformation of substances containing various functional groups (both endo- and exogenous compounds), including quinones, epoxidones and hydroperoxides [2]