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It has been acknowledged that the amount of oxygen taken up per specific time and body weight is inversely correlated with the maximum life span of species

141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

Long-term efficacy studies indicate that many patients can achieve and maintain reasonable disease control with a continuous treatment methodology, especially when combined with folic acid supplementation to mitigate side effects

it is a mechanism of innate immunity with a key role in immunosurveillance [226]