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Nat Chem Biol (2019) 15:6819

Surgeon 10, 107113 (2012)

doi: 10.1038/s41586-021-03207-w 66 NatarajanAZlitniSBrooksEFVanceSEDahlenAHedlinHet al

Pathophysiological Mechanisms of Ocular Nutrition Oxidative Stress and Antioxidant Defense Systems The retinal environment, particularly the macula, exists under conditions of high oxidative stress due to intense light exposure, elevated oxygen consumption, and abundant polyunsaturated fatty acids