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They also have a wide range of proinflammatory actions relevant to asthma and allergic disease, including mucus hypersecretion, impaired mucociliary clearance, vascular hyperpermeability, neuropeptide release, eosinophil recruitment, bronchial smooth-muscle hypertrophy, and fibroblast collagen deposition

SCY, J-IC, and SP contributed to the clinical interpretation of the findings