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Promote renal calcium reabsorption Renal tubular calcium transport: upregulate the expression of renal tubular calcium channel (TRPV5), reduce urinary calcium excretion by 30% -40%, increase blood calcium concentration, and increase bone calcium deposition Evidence from preclinical studies on AOD 9604 bone protection (animal experiments) Postmenopausal osteoporosis (OVX rat model) Experimental Design: Animal: 6-month-old female SD rats underwent bilateral ovariectomy (OVX) to establish a postmenopausal osteoporosis model

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Loss of skeletal muscle estrogen-related receptors leads to severe exercise intolerance The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB Losby, McKenna et al

However, protocols extending beyond 6 months in humans rely on extrapolation rather than controlled studies