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2.2.4 Structure-guided strategy: programmable decoupling via aptamerABP pairs Structure-guided encapsulation represents the most advanced regime of programmable loading, utilizing orthogonal, lock-and-key interactions between engineered RNA/DNA aptamers and their cognate binding proteins (ABPs) to direct cargo sequestration (Figure 3D

3a), and neurotrophic factors, GDNF and BDNF (Fig

Materials and Methods Cell Culture The human retinal pigment epithelium cell line, ARPE-19 (ATCC, Manassas, USA), was cultured in Dulbeccos modified Eagles medium Nutrient Mixture F-12 (1:1 mixture of Dulbeccos modified Eagles medium and Hams F12

While WADA is primarily concerned with systemic effects that enhance performance, any route of administration of a prohibited substance is a violation