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Future directions Future research should aim to elucidate the molecular and cellular pathways by which tobacco smoke and vaping constituents drive liver injury, immune dysregulation, and carcinogenesis

We demonstrated the presence of eNAPRT in sera from patients with a diagnosis of cancer, including solid tumors (prostate, lung and bladder cancer, mesothelioma and metastatic melanoma) and hematological malignancies [myeloma, chronic lymphocytic leukemia (CLL), and diffuse large cell lymphoma (DLCL)] (124) as summarized in Table 1

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DTNB modification of SH groups of isocitrate dehydrogenase from Bacillus stearothermophilus purified by affinity chromatography