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Fatty Acid ester of Hydroxyl Fatty Acid (FAHFAs) are adipocyte derived lipokines that can improve insulin sensitivity by suppressing endogenous glucose production in liver through G i protein coupled receptors and enhance insulin action in adipocytes (155)

Diabetes Care 20:374380 Rajpathak SN, Gunter MJ, Wylie-Rosett J et al (2009) The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes

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Then, they need supplements