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PARP-1 is a member of the PARP enzyme family consisting of PARP-1 and many additional poly-(ADP-ribosylating) enzymes

Disease-specific features are described across Alzheimers disease, Parkinsons disease, Multiple sclerosis, and Amyotrophic lateral sclerosis, emphasizing the distinct and overlapping pathways through which gut dysbiosis may contribute to pathogenesis

Our research team previously demonstrated that the estrogen/GPER/PKA signaling axis in cancer-associated fibroblasts (CAFs) within triple-negative breast cancer mediates the synthesis and secretion of lactic acid and glutamine, exacerbating the metabolic remodeling of breast cancer and leading to multidrug resistance in tumor cells [227, 243], a process known as the reverse Warburg effect

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery