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2.2 Iron metabolism Iron metabolism plays a critical role in ferroptosis, with free iron serving as the foundation for this process ( 2+ is stored in ferritin in the form of labile iron pool (LIP)

9 T cells regulate chondrocyte function and homeostasis by secreting cytokines and growth factors In the OA microenvironment, T cells regulate chondrocyte function and homeostasis by secreting cytokines and growth factors (108)

Not every subgroup participates in autophagy, but it is likely that early on in the LECA era, two ATG protein families - Atg1/ULK and PROPPINs - which interact with polyphosphoinositides, had already branched out into various subgroups

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