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In experimental SS mouse model, intra-glandular injection of anti-CD103 monoclonal antibody effectively reduces tissue-resident memory T cells, alleviates gland damage, and enhances salivary function

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HIF-1 is a transcription factor that controls several genes required to maintain a balance between oxygen supply and metabolic demand 53

Smoking is also associated with higher homocysteine levels.[ref][ref][ref] Folate and B12 status: In general, higher folate and vitamin B12 levels are associated with lower homocysteine levels.[ref] This association holds true with aging.[ref] Amount of methionine in the diet: Methionine is an essential amino acid found in protein-rich foods