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They are central to understanding when GHRP-6 makes sense and when a different secretagogue serves the research protocol better

High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

This is the reason glutathione is most often used in skin whitening treatments

Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling