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Circulating cell-free DNA (cfDNA) is also a promising biomarker which can be detected in blood, stool or urine samples for cancer screening and estimating the therapeutic response, as well as identifying collateral damage in the tissues found in the proximity of the tumor, since DNA methylation can differentiate between malignant and non-malignant cells [70, 81]

[DOI] [PubMed] [Google Scholar] 145.Fujiwara S., Kawazoe T., Ohnishi K., Kitagawa T., Popa C., Valls M., Genin S., Nakamura K., Kuramitsu Y., Tanaka N., et al

Finally, ubiquitin, Uch-L1, and the proteasome can be manipulated pharmacologically providing convenient methods for research applications and suggesting the possibility that further efforts in this field should include investigation of the potential utility of drugs that target these molecules

This underscores the imperative for early intervention and deeper mechanistic investigation into microglial activation to develop strategies that halt disease progression at its initial stages