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or an N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof, with the proviso that: when R 3 is ethyl, R 1 and R 2 cannot be both H, O, or when R 3 is ethyl and at least one of R 1 or R 2 is H, R 1 or R 2 cannot be As used herein, the terms modulate, modulating, modulator and grammatical variations thereof mean to change, such as decreasing or reducing the occurrence of ferroptosis

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