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The pathophysiological processes are multi-factorial and involve oxidative stress, apoptotic mechanisms, altered calcium homeostasis, axon degeneration and membrane remodeling as well as immune processes and neuroinflammation

In a double blind, dosing range study, the group that used topic malassezin twice a day for 8 weeks had a 30.13% reduction in the severity of hyperpigmentation, compared with 16.67% in the placebo group

Regular monitoring of Glutathione Reductase activity is essential for tracking progress and making necessary adjustments to the treatment plan

Depending on the clinical situation, a provider may review waist measurements, body composition, laboratory findings, symptoms, photographs, or other relevant health markers rather than scale weight alone