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doi: 10.3389/fcimb.2019.00042 Received 17 September 2018 Accepted 08 February 2019 Published 04 March 2019 Volume 9 - 2019 Edited by Saliha Durmu, Gebze Technical University, Turkey Reviewed by Fernando Navarro-Garcia, Centro de Investigacin y de Estudios Avanzados (CINVESTAV), Mexico

The levels of OS markers, including protein carbonyls, 4-hydroxy-2-non-enal (HNE), 3-nitrotyrosine (3-NT), and 8-OHdG, are increased in the blood and cerebrospinal fluid of patients with AD (172, 173)

in Nature Medicine found that NNMT inhibition in white adipose tissue increased energy expenditure and reduced fat mass in animal models without altering food intake or physical activity (Kraus et al., Nature Medicine )

J Physiol Paris 95(16):337344 Watanabe K, Konno S, Sekiguchi M, Kikuchi S (2007) Spinal stenosis: assessment of motor function, VEGF expression and angiogenesis in an experimental model in the rat