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However, Nrf2 acts as a double-edged sword having both antioncogenic and prooncogenic activities

A meta-analysis by Iv et al

Studies have shown that the coupling of ACSS2 and KAT7 can regulate H3K9bhb modification to promote the transcription of tumour-related genes (such as SAMD9 and FRMD3), thereby affecting the proliferation and invasion of tumour cells (75)