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Considering the heterogenicity of the tumor and its microenvironment, modulation of autophagy should be assessed on a case-by-case basis depending on specific tumor types and biomarkers to avoid adverse effects (291, 310312)

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paracellular) and does BT or uptake of endotoxins take place at baseline or only under stressed conditions

However, there is no unified conclusion on the predictive indicators of the efficacy of bevacizumab at present, and it is still impossible to confirm which group of people is suitable for bevacizumab treatment