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TPGSs formulated encapsulating silymarin, introducing particle sizes of less than 100 nm, encapsulation efficiency of more than 90%, and 5.2-fold improvement in the bioavailability of the drugs accompanying oral administration in animal models ( 5.2 Nanocrystals Nanocrystals reflect a purely nanoparticulated drug particle approach, with no solubilising excipient effects, thereby retaining high drug loading

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Despite these findings, the high levels of GHSR1a expression used in experiments identifying GHSR1as constitutive activity may be the source of this unusually high basal activity