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Narcoleptics may not be able to experience the amount of restorative deep sleep that healthy people experience due to abnormal REM regulation they are not "oversleeping." Narcoleptics typically have higher REM sleep density than non-narcoleptics, but also experience more REM sleep without atonia

This results in a reduced capacity for ketone body production, which further limits the body's ability to adapt to fasting or prolonged energy deprivation

must be factored into the analyses to isolate the effects of supplemental leucine as a stand-alone, or if taken with other branched-chain amino acids (BCAAs)

Efficacy of the New Generation of Devices for Positional Therapy for Patients With Positional Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis