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Chemical Research in Toxicology, 18 , 415419

Studies have shown that cultivation of primary macrophages on stiff ECM surfaces can affect their migration speed, morphology, proliferation, and phagocytic activity ( Several studies have indicated that collagen can stimulate M2-polarization of macrophages in vivo

While zinc deficiency leads to systemic impairment of biological processes, zinc excess exerts its toxicity primarily through the competitive inhibition of the absorption of other essential minerals (e.g., Cu and Fe) and the disruption of the gut microbial ecology, potentially promoting antibiotic resistance

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