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The FDAs final determination will follow separately, on a timeline the agency has not specified

Diagnostic Efficacy Documentation For therapeutic facet injections, most Medicare Administrative Contractors (MACs) require documentation that a previous diagnostic injection produced 50% temporary pain relief for a specified duration (commonly 24 hours for diagnostic MBB, 50% relief from facet injection)

Hepatic and Metabolic Benefits A MAFLD/MASLD (metabolic dysfunction-associated steatotic liver disease) sub-study of the Phase 2 obesity trial reported that over 85% of participants on the highest retatrutide doses achieved more than 30% reduction in liver fat content measured by MRI, with many reaching complete resolution of steatosis

The most common cause in the UK is pernicious anaemia, an autoimmune condition preventing B12 absorption